Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics

Andrew Moore, Anne Crossley, Bernard Ng, Lawrence D. Phillips, Özgür Sancak and K.D. Rainsford

LSE Research Online Documents on Economics from London School of Economics and Political Science, LSE Library

Abstract: Objectives : To test the ability of a multi-criteria decision analysis (MCDA) model to incorporate disparate data sources of varying quality along with clinical judgement in a benefit-risk assessment of six well-known pain-relief drugs. Methods: Six OTC analgesics were evaluated against three favourable effects and eight unfavourable effects by seven experts who specialise in the relief of pain, two in a two-day facilitated workshop whose input data and judgements were later peer-reviewed by five additional experts. Key findings: Ibuprofen salts & solubilised emerged with the best benefit-risk profile, followed by naproxen, ibuprofen acid, diclofenac, paracetamol, and aspirin. Conclusions: MCDA enabled participants to evaluate the OTC analgesics against a range of favourable and unfavourable effects in a group setting that enabled all issues to be openly aired and debated. The model was easily communicated and understood by the peer reviewers, so the model should be comprehensible to physicians, pharmacists, and other health professionals

Keywords: OTC analgesics; MCDA; group judgements; decision conferencing; pain relief (search for similar items in EconPapers)
JEL-codes: J50 (search for similar items in EconPapers)
Date: 2017-07-13
New Economics Papers: this item is included in nep-hea
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Citations: View citations in EconPapers (2)

Published in Journal of Pharmacy and Pharmacology, 13, July, 2017, 69(10), pp. 1364-1373. ISSN: 2042-7158

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