Copula-based modelling of self-reported health states: an application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease

Stephen Pudney and Monica Hernandez-Alava
Authors registered in the RePEc Author Service: Monica Hernandez Alava

No 2016-04, ISER Working Paper Series from Institute for Social and Economic Research

Abstract: EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument generating a description of health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but little is known about the consequences of this change. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse the joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people affected by rheumatoid disease, and use it to generate mappings between the 3-level and 5-level descriptive systems. We find significant conflicts between the two, which would imply the reversal of an important conclusion in a real-world evaluation of drug therapies.

Date: 2016-02-24
New Economics Papers: this item is included in nep-hea
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