Circadian Modulation of the Antioxidant Effect of Grape Consumption: A Randomized Controlled Trial
Cynthia Blanton (blancynt@isu.edu),
Biwash Ghimire,
Sana Khajeh Pour and
Ali Aghazadeh-Habashi (habaali@isu.edu)
Additional contact information
Cynthia Blanton: Department of Nutrition and Dietetics, Idaho State University, Pocatello, ID 83209, USA
Biwash Ghimire: Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, USA
Sana Khajeh Pour: Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, USA
Ali Aghazadeh-Habashi: Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, USA
IJERPH, 2023, vol. 20, issue 15, 1-17
Abstract:
Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 × 2 factorial randomized, controlled design wherein healthy men and women ( n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1–6. F-2 isoprostane levels showed main effects of time period (baseline < hour 1 < hours 1–6, p < 0.0001), time (a.m. > p.m., p = 0.008) and treatment (placebo > grape, p = 0.05). Total F2-isoprostane excretion expressed as % baseline was higher in the a.m. vs. p.m. ( p = 0.004) and in the a.m. placebo vs. all other groups ( p < 0.05). Tartaric acid and resveratrol excretion levels were higher in the grape vs. placebo group ( p < 0.05) but were not correlated with F-2 isoprostane levels. The findings support a protective effect of grape consumption against morning sensitivity to oxidative stress.
Keywords: circadian; grape; oxidative stress; F2-isoprostanes; tartaric acid; resveratrol; quercetin; catechin (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: Add references at CitEc
Citations:
Downloads: (external link)
https://www.mdpi.com/1660-4601/20/15/6502/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/15/6502/ (text/html)
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:15:p:6502-:d:1208997
Access Statistics for this article
IJERPH is currently edited by Ms. Jenna Liu
More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager (indexing@mdpi.com).