Translational research: from basic research to regional biomedical entrepreneurship

Sang-Min Park () and Nicholas S. Vonortas ()
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Sang-Min Park: Sejong Finance Center II
Nicholas S. Vonortas: George Washington University

Small Business Economics, 2023, vol. 60, issue 4, No 20, 1783 pages

Abstract: Abstract This paper examines the effect of translational research on knowledge production and biomedical entrepreneurship across U.S. regions. Researchers have earlier investigated the outputs of translational research by focusing on academic publications. Little attention has been paid to linking translational research to biomedical entrepreneurship. We construct an analytical model based on the knowledge spillover theory of entrepreneurship and the entrepreneurial ecosystem approach to examine the relationship between translational research, biomedical patents, clinical trials, and biomedical entrepreneurship. We test the model across 381 U.S. metropolitan statistical areas using 10 years of panel data related to the NIH Clinical and Translational Science Awards (CTSA) program. CTSA appears to increase the number of biomedical patents and biomedical entrepreneurship as proxied by the NIH Small Business Innovation Research (SBIR) grants. However, the magnitudes of the effects are relatively small. Path analysis shows that the effect of translational research on regional biomedical entrepreneurship is not strongly conveyed through biomedical patents or clinical trials.

Keywords: Translational research; CTSA; Biomedical; SBIR; Entrepreneurship; Ecosystem (search for similar items in EconPapers)
JEL-codes: L26 L65 O31 R11 (search for similar items in EconPapers)
Date: 2023
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DOI: 10.1007/s11187-022-00676-9

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