Single cell atlas for 11 non-model mammals, reptiles and birds

Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua (), Yahong Liu (), Huan Liu () and Xun Xu ()
Additional contact information
Dongsheng Chen: BGI-Shenzhen
Jian Sun: South China Agricultural University
Jiacheng Zhu: BGI-Shenzhen
Xiangning Ding: BGI-Shenzhen
Tianming Lan: BGI-Shenzhen
Xiran Wang: South China Agricultural University
Weiying Wu: BGI-Shenzhen
Zhihua Ou: BGI-Shenzhen
Linnan Zhu: BGI-Shenzhen
Peiwen Ding: BGI-Shenzhen
Haoyu Wang: BGI-Shenzhen
Lihua Luo: BGI-Shenzhen
Rong Xiang: BGI-Shenzhen
Xiaoling Wang: BGI-Shenzhen
Jiaying Qiu: BGI-Shenzhen
Shiyou Wang: BGI-Shenzhen
Haimeng Li: BGI-Shenzhen
Chaochao Chai: BGI-Shenzhen
Langchao Liang: BGI-Shenzhen
Fuyu An: Guangdong Academy of Forestry
Le Zhang: College of Wildlife Resources Northeast Forestry University
Lei Han: College of Wildlife Resources Northeast Forestry University
Yixin Zhu: BGI-Shenzhen
Feiyue Wang: BGI-Shenzhen
Yuting Yuan: BGI-Shenzhen
Wendi Wu: BGI-Shenzhen
Chengcheng Sun: BGI-Shenzhen
Haorong Lu: China National Genebank, BGI-Shenzhen
Jihong Wu: Fudan University
Xinghuai Sun: Fudan University
Shenghai Zhang: Fudan University
Sunil Kumar Sahu: BGI-Shenzhen
Ping Liu: BGI-Shenzhen
Jun Xia: BGI-Shenzhen
Lijing Zhang: BGI-Shenzhen
Haixia Chen: BGI-Shenzhen
Dongming Fang: BGI-Shenzhen
Yuying Zeng: BGI-Shenzhen
Yiquan Wu: National Institutes of Health
Zehua Cui: South China Agricultural University
Qian He: South China Agricultural University
Sanjie Jiang: BGI-Shenzhen
Xiaoyan Ma: University of Cambridge
Weimin Feng: BGI-Shenzhen
Yan Xu: BGI-Shenzhen
Fang Li: Tongji University School of Medicine
Zhongmin Liu: Tongji University School of Medicine
Lei Chen: Yangzhou University
Fang Chen: BGI-Shenzhen
Xin Jin: BGI-Shenzhen
Wei Qiu: The Third Affiliated Hospital of Sun Yat-Sen University
Tianjiao Wang: Institute of Special Animal and Plant Sciences (ISAPS) of Chinese Academy of Agricultural Sciences
Yang Li: Institute of Special Animal and Plant Sciences (ISAPS) of Chinese Academy of Agricultural Sciences
Xiumei Xing: Institute of Special Animal and Plant Sciences (ISAPS) of Chinese Academy of Agricultural Sciences
Huanming Yang: BGI-Shenzhen
Yanchun Xu: College of Wildlife Resources Northeast Forestry University
Yan Hua: Guangdong Academy of Forestry
Yahong Liu: South China Agricultural University
Huan Liu: BGI-Shenzhen
Xun Xu: BGI-Shenzhen

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs.

Date: 2021
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DOI: 10.1038/s41467-021-27162-2

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