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Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation

Masahiro Sawada, Ralph Adolphs, Brian J. Dlouhy, Rick L. Jenison, Ariane E. Rhone, Christopher K. Kovach, D. W. Greenlee Jeremy, Matthew A. Howard and Hiroyuki Oya (hiroyuki-oya@uiowa.edu)
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Masahiro Sawada: University of Iowa
Ralph Adolphs: California Institute of Technology
Brian J. Dlouhy: University of Iowa
Rick L. Jenison: University of Wisconsin - Madison
Ariane E. Rhone: University of Iowa
Christopher K. Kovach: University of Iowa
D. W. Greenlee Jeremy: University of Iowa
Matthew A. Howard: University of Iowa
Hiroyuki Oya: University of Iowa

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract The primate amygdala is a complex consisting of over a dozen nuclei that have been implicated in a host of cognitive functions, individual differences, and psychiatric illnesses. These functions are implemented through distinct connectivity profiles, which have been documented in animals but remain largely unknown in humans. Here we present results from 25 neurosurgical patients who had concurrent electrical stimulation of the amygdala with intracranial electroencephalography (electrical stimulation tract-tracing; es-TT), or fMRI (electrical stimulation fMRI; es-fMRI), methods providing strong inferences about effective connectivity of amygdala subdivisions with the rest of the brain. We quantified functional connectivity with medial and lateral amygdala, the temporal order of these connections on the timescale of milliseconds, and also detail second-order effective connectivity among the key nodes. These findings provide a uniquely detailed characterization of human amygdala functional connectivity that will inform functional neuroimaging studies in healthy and clinical populations.

Date: 2022
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DOI: 10.1038/s41467-022-32644-y

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