Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2
Young Rae Ji,
Yosuke Tona,
Talah Wafa,
Matthew E. Christman,
Edward D. Tourney,
Tao Jiang,
Sho Ohta,
Hui Cheng,
Tracy Fitzgerald,
Bernd Fritzsch,
Sherri M. Jones,
Kathleen E. Cullen and
Doris K. Wu (wud@nidcd.nih.gov)
Additional contact information
Young Rae Ji: National Institutes of Health
Yosuke Tona: National Institutes of Health
Talah Wafa: National Institutes of Health
Matthew E. Christman: Johns Hopkins University School of Medicine
Edward D. Tourney: Johns Hopkins University School of Medicine
Tao Jiang: National Institutes of Health
Sho Ohta: National Institutes of Health
Hui Cheng: National Institutes of Health
Tracy Fitzgerald: National Institutes of Health
Bernd Fritzsch: University of Iowa
Sherri M. Jones: University of Nebraska-Lincoln
Kathleen E. Cullen: Johns Hopkins University School of Medicine
Doris K. Wu: National Institutes of Health
Nature Communications, 2022, vol. 13, issue 1, 1-14
Abstract:
Abstract Otolith organs of the inner ear are innervated by two parallel afferent projections to the brainstem and cerebellum. These innervations were proposed to segregate across the line of polarity reversal (LPR) within each otolith organ, which divides the organ into two regions of hair cells (HC) with opposite stereociliary orientation. The relationship and functional significance of these anatomical features are not known. Here, we show regional expression of Emx2 in otolith organs, which establishes LPR, mediates the neuronal segregation across LPR and constitutes the bidirectional sensitivity function. Conditional knockout (cKO) of Emx2 in HCs lacks LPR. Tmie cKO, in which mechanotransduction was abolished selectively in HCs within the Emx2 expression domain also lacks bidirectional sensitivity. Analyses of both mutants indicate that LPR is specifically required for mice to swim comfortably and to traverse a balance beam efficiently, but LPR is not required for mice to stay on a rotating rod.
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33819-3
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DOI: 10.1038/s41467-022-33819-3
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