Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Daan K. J. Pieren, Sebastián G. Kuguel, Joel Rosado, Alba G. Robles, Joan Rey-Cano, Cristina Mancebo, Juliana Esperalba, Vicenç Falcó, María J. Buzón and Meritxell Genescà ()
Additional contact information
Daan K. J. Pieren: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Sebastián G. Kuguel: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Joel Rosado: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Alba G. Robles: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Joan Rey-Cano: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Cristina Mancebo: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Juliana Esperalba: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Vicenç Falcó: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
María J. Buzón: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
Meritxell Genescà: Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Resident memory T cells (TRM) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting viral infection and disease. While long-term antigen-specific TRM are detectable beyond 11 months in the lung of convalescent COVID-19 patients, it is unknown if mRNA vaccination encoding for the SARS-CoV-2 S-protein can induce this frontline protection. Here we show that the frequency of CD4+ T cells secreting IFNγ in response to S-peptides is variable but overall similar in the lung of mRNA-vaccinated patients compared to convalescent-infected patients. However, in vaccinated patients, lung responses present less frequently a TRM phenotype compared to convalescent infected individuals and polyfunctional CD107a+ IFNγ+ TRM are virtually absent in vaccinated patients. These data indicate that mRNA vaccination induces specific T cell responses to SARS-CoV-2 in the lung parenchyma, although to a limited extend. It remains to be determined whether these vaccine-induced responses contribute to overall COVID-19 control.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-37559-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37559-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-37559-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().