Microbes translocation from oral cavity to nasopharyngeal carcinoma in patients

Ying Liao, Yan-Xia Wu, Minzhong Tang, Yi-Wei Chen, Jin-Ru Xie, Yan Du, Tong-Min Wang, Yong-Qiao He, Wen-Qiong Xue, Xiao-Hui Zheng, Qiao-Yun Liu, Mei-Qi Zheng, Yi-Jing Jia, Xia-Ting Tong, Ting Zhou, Xi-Zhao Li, Da-Wei Yang, Hua Diao and Wei-Hua Jia ()
Additional contact information
Ying Liao: Sun Yat-sen University Cancer Center
Yan-Xia Wu: Sun Yat-sen University Cancer Center
Minzhong Tang: Wuzhou Red Cross Hospital
Yi-Wei Chen: Sun Yat-sen University Cancer Center
Jin-Ru Xie: Sun Yat-sen University Cancer Center
Yan Du: Sun Yat-sen University Cancer Center
Tong-Min Wang: Sun Yat-sen University Cancer Center
Yong-Qiao He: Sun Yat-sen University Cancer Center
Wen-Qiong Xue: Sun Yat-sen University Cancer Center
Xiao-Hui Zheng: Sun Yat-sen University Cancer Center
Qiao-Yun Liu: Sun Yat-sen University
Mei-Qi Zheng: Sun Yat-sen University Cancer Center
Yi-Jing Jia: Sun Yat-sen University
Xia-Ting Tong: Sun Yat-sen University
Ting Zhou: Sun Yat-sen University Cancer Center
Xi-Zhao Li: Sun Yat-sen University Cancer Center
Da-Wei Yang: Sun Yat-sen University
Hua Diao: Sun Yat-sen University
Wei-Hua Jia: Sun Yat-sen University Cancer Center

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The presence of oral microbes in extra-oral sites is linked to gastrointestinal cancers. However, their potential ectopically colonization in the nasopharynx and impact on local cancer development remains uncertain. Our study involving paired nasopharyngeal-oral microbial samples from nasopharyngeal carcinoma (NPC) patients and controls unveils an aberrant oral-to-nasopharyngeal microbial translocation associated with increased NPC risk (OR = 4.51, P = 0.012). Thirteen species are classified as oral-translocated and enriched in NPC patients. Among these, Fusobacterium nucleatum and Prevotella intermedia are validated through culturomics and clonal strain identification. Nasopharyngeal biopsy meta-transcriptomes confirm these microbes within tumors, influencing local microenvironment and cytokine response. These microbes correlate significantly with the Epstein-Barr virus (EBV) loads in the nasopharynx, exhibiting an increased dose-response relationship. Collectively, our study identifies oral microbes migrating to the nasopharynx, infiltrating tumors, impacting microenvironments and linking with EBV infection. These results enhance our understanding of abnormal microbial communication and their roles in carcinogenesis.

Date: 2024
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DOI: 10.1038/s41467-024-45518-2

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