PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

Jong Geol Lee, Jung-Min Yon, Globinna Kim, Seul-Gi Lee, C-Yoon Kim, Seung-A Cheong, Hyun-Yi Kim, Jiyoung Yu, Kyunggon Kim, Young Hoon Sung, Hyun Ju Yoo, Dong-Cheol Woo, Jin Kyung Rho, Chang Hoon Ha, Chan-Gi Pack, Seak Hee Oh, Joon Seo Lim, Yu Mi Han, Eui-Ju Hong, Je Kyung Seong, Han-Woong Lee, Sang-Wook Lee, Ki-Up Lee, Chong Jai Kim, Sang-Yoon Nam, You Sook Cho () and In-Jeoung Baek ()
Additional contact information
Jong Geol Lee: Asan Medical Center
Jung-Min Yon: Asan Medical Center
Globinna Kim: Asan Medical Center
Seul-Gi Lee: Konkuk University
C-Yoon Kim: Konkuk University
Seung-A Cheong: Asan Medical Center
Hyun-Yi Kim: NGeneS Inc
Jiyoung Yu: Asan Medical Center
Kyunggon Kim: Asan Medical Center
Young Hoon Sung: Asan Medical Center
Hyun Ju Yoo: Asan Medical Center
Dong-Cheol Woo: Asan Medical Center
Jin Kyung Rho: Asan Medical Center
Chang Hoon Ha: Asan Medical Center
Chan-Gi Pack: Asan Medical Center
Seak Hee Oh: University of Ulsan College of Medicine
Joon Seo Lim: Asan Medical Center
Yu Mi Han: Sungkyunkwan University School of Medicine
Eui-Ju Hong: Chungnam National University
Je Kyung Seong: Korea Mouse Phenotyping Center (KMPC)
Han-Woong Lee: Yonsei University
Sang-Wook Lee: Korea Mouse Phenotyping Center (KMPC)
Ki-Up Lee: Asan Medical Center
Chong Jai Kim: Asan Medical Center
Sang-Yoon Nam: Chungbuk National University
You Sook Cho: Asan Medical Center
In-Jeoung Baek: Asan Medical Center

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through which the placenta influences the development of embryonic organs remains unclear. Trophoblasts fuse to form multinucleated syncytiotrophoblasts (SynT), which primarily make up the placental materno-fetal interface. We discovered that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) is vital for trophoblast differentiation and fusion into SynT in humans and mice. PIBF1 facilitates communication between SynT and adjacent vascular cells, promoting vascular network development in the primary placenta. This process affected the early development of the embryonic cardiovascular system in mice. Moreover, in vitro experiments showed that PIBF1 promotes the development of cardiovascular characteristics in heart organoids. Our findings show how SynTs organize the barrier and imply their possible roles in supporting embryogenesis, including cardiovascular development. SynT-derived factors and SynT within the placenta may play critical roles in ensuring proper organogenesis of other organs in the embryo.

Date: 2024
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DOI: 10.1038/s41467-024-45647-8

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