Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Volker Gerke (), Felicity N. E. Gavins, Michael Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted and Ursula Rescher ()
Additional contact information
Volker Gerke: University of Münster
Felicity N. E. Gavins: Brunel University London
Michael Geisow: The National Institute for Medical Research, Mill Hill
Thomas Grewal: University of Sydney
Jyoti K. Jaiswal: Children’s National Research and Innovation Campus
Jesper Nylandsted: Danish Cancer Institute
Ursula Rescher: University of Münster

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-024-45954-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45954-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-45954-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().