Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

Andrea I. Luppi (), Lynn Uhrig, Jordy Tasserie, Camilo M. Signorelli, Emmanuel A. Stamatakis, Alain Destexhe, Bechir Jarraya and Rodrigo Cofre ()
Additional contact information
Andrea I. Luppi: University of Cambridge
Lynn Uhrig: Université Paris-Saclay, NeuroSpin Center
Jordy Tasserie: Université Paris-Saclay, NeuroSpin Center
Camilo M. Signorelli: Université Paris-Saclay, NeuroSpin Center
Emmanuel A. Stamatakis: University of Cambridge
Alain Destexhe: Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS)
Bechir Jarraya: Université Paris-Saclay, NeuroSpin Center
Rodrigo Cofre: Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS)

Nature Communications, 2024, vol. 15, issue 1, 1-22

Abstract: Abstract A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI coverage of the entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, and subsequent restoration of responsiveness by electrical stimulation of the central thalamus, we investigate how loss of consciousness impacts distributed patterns of structure-function organisation across scales. We report that distributed brain activity under anaesthesia is increasingly constrained by brain structure across scales, coinciding with anaesthetic-induced collapse of multiple dimensions of hierarchical cortical organisation. These distributed signatures are observed across different anaesthetics, and they are reversed by electrical stimulation of the central thalamus, coinciding with recovery of behavioural markers of arousal. No such effects were observed upon stimulating the ventral lateral thalamus, demonstrating specificity. Overall, we identify consistent distributed signatures of consciousness that are orchestrated by specific thalamic nuclei.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-46382-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46382-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-46382-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().