Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation

Ying Wang, Vinod K. Paidi, Weizhen Wang, Yong Wang, Guangri Jia, Tingyu Yan, Xiaoqiang Cui, Songhua Cai (), Jingxiang Zhao (), Kug-Seung Lee (), Lawrence Yoon Suk Lee () and Kwok-Yin Wong ()
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Ying Wang: Hung Hom
Vinod K. Paidi: European Synchrotron Radiation Facility
Weizhen Wang: The Hong Kong Polytechnic University, Hung Hom
Yong Wang: Hung Hom
Guangri Jia: Jilin University
Tingyu Yan: Harbin Normal University
Xiaoqiang Cui: Jilin University
Songhua Cai: The Hong Kong Polytechnic University, Hung Hom
Jingxiang Zhao: Harbin Normal University
Kug-Seung Lee: Pohang University of Science and Technology (POSTECH)
Lawrence Yoon Suk Lee: Hung Hom
Kwok-Yin Wong: Hung Hom

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of heterogeneous SAzymes configurations and homogeneous enzyme-like mechanism remains an enormous challenge. Here, we show a spatial engineering strategy to fabricate dual-sites SAzymes with atomic Fe active center and adjacent Cu sites. Compared to planar Fe–Cu dual-atomic sites, vertically stacked Fe–Cu geometry in FePc@2D-Cu–N–C possesses highly optimized scaffolds, favorable substrate affinity, and fast electron transfer. These characteristics of FePc@2D-Cu–N–C SAzyme induces biomimetic O2 activation through homogenous enzymatic pathway, resembling functional and mechanistic similarity to natural cytochrome c oxidase. Furthermore, it presents an appealing alternative of cytochrome P450 3A4 for drug metabolism and drug–drug interaction. These findings are expected to deepen the fundamental understanding of atomic-level design in next-generation bio-inspired nanozymes.

Date: 2024
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DOI: 10.1038/s41467-024-46528-w

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