Noncovalent interaction with a spirobipyridine ligand enables efficient iridium-catalyzed C–H activation

Yushu Jin, Boobalan Ramadoss, Sobi Asako () and Laurean Ilies ()
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Yushu Jin: RIKEN Center for Sustainable Resource Science
Boobalan Ramadoss: RIKEN Center for Sustainable Resource Science
Sobi Asako: RIKEN Center for Sustainable Resource Science
Laurean Ilies: RIKEN Center for Sustainable Resource Science

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Exploitation of noncovalent interactions for recognition of an organic substrate has received much attention for the design of metal catalysts in organic synthesis. The CH–π interaction is especially of interest for molecular recognition because both the C–H bonds and the π electrons are fundamental properties of organic molecules. However, because of their weak nature, these interactions have been less utilized for the control of organic reactions. We show here that the CH–π interaction can be used to kinetically accelerate catalytic C–H activation of arenes by directly recognizing the π-electrons of the arene substrates with a spirobipyridine ligand. Computation and a ligand kinetic isotope effect study provide evidence for the CH–π interaction between the ligand backbone and the arene substrate. The rational exploitation of weak noncovalent interactions between the ligand and the substrate will open new avenues for ligand design in catalysis.

Date: 2024
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DOI: 10.1038/s41467-024-46893-6

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