Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice

Laurence D. W. Luu, Abhimanu Pandey, Sudarshan Paramsothy, Chinh Ngo, Natalia Castaño-Rodríguez, Cheng Liu, Michael A. Kamm, Thomas J. Borody, Si Ming Man and Nadeem O. Kaakoush ()
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Laurence D. W. Luu: UNSW
Abhimanu Pandey: The Australian National University
Sudarshan Paramsothy: The University of Sydney
Chinh Ngo: The Australian National University
Natalia Castaño-Rodríguez: UNSW
Cheng Liu: QIMR Berghofer Medical Research Institute
Michael A. Kamm: St Vincent’s Hospital
Thomas J. Borody: Centre for Digestive Diseases
Si Ming Man: The Australian National University
Nadeem O. Kaakoush: UNSW

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo to identify molecules regulated during disease remission. FMT alters the transcriptome above the effect of placebo (n = 75 vs 3 genes, q

Date: 2024
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DOI: 10.1038/s41467-024-46983-5

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