Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears

Xihao Pan, Rui Li, Wenyue Li, Wei Sun, Yiyang Yan, Xiaochen Xiang, Jinghua Fang, Youguo Liao, Chang Xie, Xiaozhao Wang, Youzhi Cai, Xudong Yao and Hongwei Ouyang ()
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Xihao Pan: and Liangzhu Laboratory, Zhejiang University School of Medicine
Rui Li: and Liangzhu Laboratory, Zhejiang University School of Medicine
Wenyue Li: and Liangzhu Laboratory, Zhejiang University School of Medicine
Wei Sun: and Liangzhu Laboratory, Zhejiang University School of Medicine
Yiyang Yan: and Liangzhu Laboratory, Zhejiang University School of Medicine
Xiaochen Xiang: Zhejiang University School of Medicine
Jinghua Fang: Zhejiang University
Youguo Liao: and Liangzhu Laboratory, Zhejiang University School of Medicine
Chang Xie: and Liangzhu Laboratory, Zhejiang University School of Medicine
Xiaozhao Wang: and Liangzhu Laboratory, Zhejiang University School of Medicine
Youzhi Cai: School of Medicine, Zhejiang University
Xudong Yao: International Institutes of Medicine, Zhejiang University School of Medicine
Hongwei Ouyang: and Liangzhu Laboratory, Zhejiang University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration. Supramolecular interactions of β-sheets and hydrogen bonds richened by phenylboronic acid-ionic liquid (PIL) result in enhanced wet adhesion, swelling resistance, and anti-fatigue capabilities, compared to neat silk fibroin gel. Besides, elimination of reactive oxygen species (ROS) by S-PIL10 further fortifies localized meniscus tear repair by affecting inflammatory microenvironment with dynamic borate ester bonds, and S-PIL10 continuously releases TGF-β1 for cell recruitment and bridging of defect edge. In vivo rabbit models functionally evidence the seamless and dense reconstruction of torn meniscus, verifying that the concept of meniscus adhesive is feasible and providing a promising revolutionary strategy for preclinical research to repair meniscus tears.

Date: 2024
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DOI: 10.1038/s41467-024-47029-6

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