A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

Giovanni Maria Matrone (), Eveline R. W. Doremaele, Abhijith Surendran, Zachary Laswick, Sophie Griggs, Gang Ye, Iain McCulloch, Francesca Santoro, Jonathan Rivnay and Yoeri Burgt ()
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Giovanni Maria Matrone: Eindhoven University of Technology
Eveline R. W. Doremaele: Eindhoven University of Technology
Abhijith Surendran: Northwestern University
Zachary Laswick: Northwestern University
Sophie Griggs: Chemistry Research Laboratory, University of Oxford
Gang Ye: Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University
Iain McCulloch: Chemistry Research Laboratory, University of Oxford
Francesca Santoro: Istituto Italiano di Tecnologia
Jonathan Rivnay: Northwestern University
Yoeri Burgt: Eindhoven University of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Signal communication mechanisms within the human body rely on the transmission and modulation of action potentials. Replicating the interdependent functions of receptors, neurons and synapses with organic artificial neurons and biohybrid synapses is an essential first step towards merging neuromorphic circuits and biological systems, crucial for computing at the biological interface. However, most organic neuromorphic systems are based on simple circuits which exhibit limited adaptability to both external and internal biological cues, and are restricted to emulate only specific the functions of an individual neuron/synapse. Here, we present a modular neuromorphic system which combines organic spiking neurons and biohybrid synapses to replicate a neural pathway. The spiking neuron mimics the sensory coding function of afferent neurons from light stimuli, while the neuromodulatory activity of interneurons is emulated by neurotransmitters-mediated biohybrid synapses. Combining these functions, we create a modular connection between multiple neurons to establish a pre-processing retinal pathway primitive.

Date: 2024
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DOI: 10.1038/s41467-024-47226-3

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