A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration

Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Jürgen Graf, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff and Manuel Teichert ()
Additional contact information
Simon Weiler: University College London
Vahid Rahmati: Department of Neurology
Marcel Isstas: Institute of General Zoology and Animal Physiology
Johann Wutke: Department of Neurology
Andreas Walter Stark: Institute of Applied Optics and Biophysics
Christian Franke: Institute of Applied Optics and Biophysics
Jürgen Graf: Department of Neurology
Christian Geis: Department of Neurology
Otto W. Witte: Department of Neurology
Mark Hübener: Max Planck Institute for Biological Intelligence
Jürgen Bolz: Institute of General Zoology and Animal Physiology
Troy W. Margrie: University College London
Knut Holthoff: Department of Neurology
Manuel Teichert: Department of Neurology

Nature Communications, 2024, vol. 15, issue 1, 1-24

Abstract: Abstract Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of the whisker array, brain-wide anatomical tracing and functional connectivity analysis to explore the possibility of tacto-visual convergence in sensory space and within the circuitry of the primary visual cortex (VISp). Strikingly, we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a tacto-visual sub-region of VISp whose visual space representation closely overlaps with the whisker search space. This suppression is mediated by local fast-spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 neurons located in the posterior primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-47459-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47459-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-47459-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().