Rapid room-temperature phosphorescence chiral recognition of natural amino acids

Xiaoyu Chen, Renlong Zhu, Baicheng Zhang, Xiaolong Zhang, Aoyuan Cheng, Hongping Liu, Ruiying Gao, Xuepeng Zhang, Biao Chen (), Shuji Ye, Jun Jiang and Guoqing Zhang ()
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Xiaoyu Chen: University of Science and Technology of China
Renlong Zhu: University of Science and Technology of China
Baicheng Zhang: University of Science and Technology of China
Xiaolong Zhang: University of Science and Technology of China
Aoyuan Cheng: University of Science and Technology of China
Hongping Liu: University of Science and Technology of China
Ruiying Gao: University of Science and Technology of China
Xuepeng Zhang: University of Science and Technology of China
Biao Chen: University of Science and Technology of China
Shuji Ye: University of Science and Technology of China
Jun Jiang: University of Science and Technology of China
Guoqing Zhang: University of Science and Technology of China

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Chiral recognition of amino acids is very important in both chemical and life sciences. Although chiral recognition with luminescence has many advantages such as being inexpensive, it is usually slow and lacks generality as the recognition module relies on structural complementarity. Here, we show that one single molecular-solid sensor, L-phenylalanine derived benzamide, can manifest the structural difference between the natural, left-handed amino acid and its right-handed counterpart via the difference of room-temperature phosphorescence (RTP) irrespective of the specific chemical structure. To realize rapid and reliable sensing, the doped samples are obtained as nanocrystals from evaporation of the tetrahydrofuran solutions, which allows for efficient triplet-triplet energy transfer to the chiral analytes generated in situ from chiral amino acids. The results show that L-analytes induce strong RTP, whereas the unnatural D-analytes produce barely any afterglow. The method expands the scope of luminescence chiral sensing by lessening the requirement for specific molecular structures.

Date: 2024
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DOI: 10.1038/s41467-024-47648-z

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