Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation

Shuangshuang Wan, Kepeng Wang, Peihong Huang, Xian Guo, Wurui Liu, Yaocheng Li, Jingjing Zhang, Zhiyang Li, Jiacheng Song, Wenjing Yang, Xianzheng Zhang, Xianguang Ding (), David Tai Leong () and Lianhui Wang ()
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Shuangshuang Wan: Nanjing University of Posts and Telecommunications
Kepeng Wang: Nanjing University of Posts and Telecommunications
Peihong Huang: Nanjing University of Posts and Telecommunications
Xian Guo: Nanjing University of Posts and Telecommunications
Wurui Liu: Nanjing University of Posts and Telecommunications
Yaocheng Li: Nanjing University of Posts and Telecommunications
Jingjing Zhang: Nanjing University of Posts and Telecommunications
Zhiyang Li: Nanjing University
Jiacheng Song: The First Affiliated Hospital of Nanjing Medical University
Wenjing Yang: Nanjing University of Posts and Telecommunications
Xianzheng Zhang: Wuhan University
Xianguang Ding: Nanjing University of Posts and Telecommunications
David Tai Leong: National University of Singapore
Lianhui Wang: Nanjing University of Posts and Telecommunications

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases. While the host immune cells do produce extracellular vesicles to counteract some deleterious effects of the microbiota, the extracellular vesicles are of insufficient doses and at unreliable exposure times. Here we use mechanical stimulation of hydrogel-embedded macrophage in a bioelectronic controller that on demand boost production of up to 20 times of therapeutic extracellular vesicles to ameliorate the microbes’ deleterious effects in vivo. Our miniaturized wireless bioelectronic system termed inducible mechanical activation for in-situ and sustainable generating extracellular vesicles (iMASSAGE), leverages on wireless electronics and responsive hydrogel to impose mechanical forces on macrophages to produce extracellular vesicles that rectify gut microbiome dysbiosis and ameliorate colitis. This in vivo controllable extracellular vesicles-produced system holds promise as platform to treat various other diseases.

Date: 2024
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DOI: 10.1038/s41467-024-47710-w

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