Selenium catalysis enables negative feedback organic oscillators

Xiuxiu Li, Polina Fomitskaya, Viktoryia A. Smaliak, Barbara S. Smith, Ekaterina V. Skorb and Sergey N. Semenov ()
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Xiuxiu Li: Weizmann Institute of Science
Polina Fomitskaya: Weizmann Institute of Science
Viktoryia A. Smaliak: Weizmann Institute of Science
Barbara S. Smith: Arizona State University
Ekaterina V. Skorb: ITMO University
Sergey N. Semenov: Weizmann Institute of Science

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract The construction of materials regulated by chemical reaction networks requires regulatory motifs that can be stacked together into systems with desired properties. Multiple autocatalytic reactions producing thiols are known. However, negative feedback loop motifs are unavailable for thiol chemistry. Here, we develop a negative feedback loop based on the selenocarbonates. In this system, thiols induce the release of aromatic selenols that catalyze the oxidation of thiols by organic peroxides. This negative feedback loop has two important features. First, catalytic oxidation of thiols follows Michaelis-Menten-like kinetics, thus increasing nonlinearity for the negative feedback. Second, the strength of the negative feedback can be tuned by varying substituents in selenocarbonates. When combined with the autocatalytic production of thiols in a flow reactor, this negative feedback loop induces sustained oscillations. The availability of this negative feedback motif enables the future construction of oscillatory, homeostatic, adaptive, and other regulatory circuits in life-inspired systems and materials.

Date: 2024
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DOI: 10.1038/s41467-024-47714-6

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