Phytoalexin sakuranetin attenuates endocytosis and enhances resistance to rice blast

Lihui Jiang, Xiaoyan Zhang, Yiting Zhao, Haiyan Zhu, Qijing Fu, Xinqi Lu, Wuying Huang, Xinyue Yang, Xuan Zhou, Lixia Wu, Ao Yang, Xie He, Man Dong, Ziai Peng, Jing Yang, Liwei Guo, Jiancheng Wen, Huichuan Huang, Yong Xie, Shusheng Zhu, Chengyun Li, Xiahong He, Youyong Zhu, Jiří Friml and Yunlong Du ()
Additional contact information
Lihui Jiang: Yunnan Agricultural University
Xiaoyan Zhang: Yunnan Agricultural University
Yiting Zhao: Yunnan Agricultural University
Haiyan Zhu: Yunnan Agricultural University
Qijing Fu: Yunnan Agricultural University
Xinqi Lu: Yunnan Agricultural University
Wuying Huang: Yunnan Agricultural University
Xinyue Yang: Yunnan Agricultural University
Xuan Zhou: Yunnan Agricultural University
Lixia Wu: Yunnan Agricultural University
Ao Yang: Yunnan Agricultural University
Xie He: Yunnan Agricultural University
Man Dong: Yunnan Agricultural University
Ziai Peng: Yunnan Agricultural University
Jing Yang: Yunnan Agricultural University
Liwei Guo: Yunnan Agricultural University
Jiancheng Wen: Yunnan Agricultural University
Huichuan Huang: Yunnan Agricultural University
Yong Xie: Yunnan Agricultural University
Shusheng Zhu: Yunnan Agricultural University
Chengyun Li: Yunnan Agricultural University
Xiahong He: Southwest Forestry University
Youyong Zhu: Yunnan Agricultural University
Jiří Friml: Institute of Science and Technology Austria (IST Austria)
Yunlong Du: Yunnan Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Phytoalexin sakuranetin functions in resistance against rice blast. However, the mechanisms underlying the effects of sakuranetin remains elusive. Here, we report that rice lines expressing resistance (R) genes were found to contain high levels of sakuranetin, which correlates with attenuated endocytic trafficking of plasma membrane (PM) proteins. Exogenous and endogenous sakuranetin attenuates the endocytosis of various PM proteins and the fungal effector PWL2. Moreover, accumulation of the avirulence protein AvrCO39, resulting from uptake into rice cells by Magnaporthe oryzae, was reduced following treatment with sakuranetin. Pharmacological manipulation of clathrin-mediated endocytic (CME) suggests that this pathway is targeted by sakuranetin. Indeed, attenuation of CME by sakuranetin is sufficient to convey resistance against rice blast. Our data reveals a mechanism of rice against M. oryzae by increasing sakuranetin levels and repressing the CME of pathogen effectors, which is distinct from the action of many R genes that mainly function by modulating transcription.

Date: 2024
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DOI: 10.1038/s41467-024-47746-y

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