Inflammation and mitophagy are mitochondrial checkpoints to aging

Emma Guilbaud, Kristopher A. Sarosiek and Lorenzo Galluzzi ()
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Emma Guilbaud: Weill Cornell Medicine
Kristopher A. Sarosiek: Harvard T.H. Chan School of Public Health
Lorenzo Galluzzi: Weill Cornell Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-3

Abstract: Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

Date: 2024
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DOI: 10.1038/s41467-024-47840-1

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