Circulating fatty acids and risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank

Zhening Liu, Hangkai Huang, Jiarong Xie, Yingying Xu and Chengfu Xu ()
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Zhening Liu: Zhejiang University School of Medicine
Hangkai Huang: Zhejiang University School of Medicine
Jiarong Xie: Zhejiang University School of Medicine
Yingying Xu: the Third People’s Hospital of Yuyao
Chengfu Xu: Zhejiang University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Nuclear magnetic resonance (NMR)-based plasma fatty acids are objective biomarkers of many diseases. Herein, we aim to explore the associations of NMR-based plasma fatty acids with the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD) mortality in 252,398 UK Biobank participants. Here we show plasma levels of n-3 poly-unsaturated fatty acids (PUFA) and n-6 PUFA are negatively associated with the risk of incident HCC [HRQ4vsQ1: 0.48 (95% CI: 0.33–0.69) and 0.48 (95% CI: 0.28–0.81), respectively] and CLD mortality [HRQ4vsQ1: 0.21 (95% CI: 0.13–0.33) and 0.15 (95% CI: 0.08–0.30), respectively], whereas plasma levels of saturated fatty acids are positively associated with these outcomes [HRQ4vsQ1: 3.55 (95% CI: 2.25–5.61) for HCC and 6.34 (95% CI: 3.68–10.92) for CLD mortality]. Furthermore, fibrosis stage significantly modifies the associations between PUFA and CLD mortality. This study contributes to the limited prospective evidence on the associations between plasma-specific fatty acids and end-stage liver outcomes.

Date: 2024
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DOI: 10.1038/s41467-024-47960-8

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