A mechanical-assisted post-bioprinting strategy for challenging bone defects repair

Jirong Yang, Zhigang Chen, Chongjian Gao, Juan Liu, Kaizheng Liu, Xiao Wang, Xiaoling Pan, Guocheng Wang, Hongxun Sang, Haobo Pan, Wenguang Liu and Changshun Ruan ()
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Jirong Yang: Chinese Academy of Sciences
Zhigang Chen: Chinese Academy of Sciences
Chongjian Gao: Chinese Academy of Sciences
Juan Liu: Chinese Academy of Sciences
Kaizheng Liu: Chinese Academy of Sciences
Xiao Wang: Chinese Academy of Sciences
Xiaoling Pan: Chinese Academy of Sciences
Guocheng Wang: Chinese Academy of Sciences
Hongxun Sang: Southern Medical University
Haobo Pan: Chinese Academy of Sciences
Wenguang Liu: Tianjin University
Changshun Ruan: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Bioprinting that can synchronously deposit cells and biomaterials has lent fresh impetus to the field of tissue regeneration. However, the unavoidable occurrence of cell damage during fabrication process and intrinsically poor mechanical stability of bioprinted cell-laden scaffolds severely restrict their utilization. As such, on basis of heart-inspired hollow hydrogel-based scaffolds (HHSs), a mechanical-assisted post-bioprinting strategy is proposed to load cells into HHSs in a rapid, uniform, precise and friendly manner. HHSs show mechanical responsiveness to load cells within 4 s, a 13-fold increase in cell number, and partitioned loading of two types of cells compared with those under static conditions. As a proof of concept, HHSs with the loading cells show an enhanced regenerative capability in repair of the critical-sized segmental and osteoporotic bone defects in vivo. We expect that this post-bioprinting strategy can provide a universal, efficient, and promising way to promote cell-based regenerative therapy.

Date: 2024
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DOI: 10.1038/s41467-024-48023-8

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