Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination
Zhusheng Huang,
Rong Gu,
Shiqian Huang,
Qian Chen,
Jing Yan,
Xiaoya Cui,
Haojie Jiang,
Dan Yao,
Chuang Shen,
Jiayue Su,
Tao Liu,
Jinhui Wu,
Zhimin Luo (iamzmluo@njupt.edu.cn),
Yiqiao Hu (huyiqiao@nju.edu.cn) and
Ahu Yuan (yuannju@nju.edu.cn)
Additional contact information
Zhusheng Huang: Nanjing University
Rong Gu: Nanjing University
Shiqian Huang: Nanjing University of Posts and Telecommunications
Qian Chen: Nanjing University
Jing Yan: Medical School of Nanjing University
Xiaoya Cui: Tsinghua University
Haojie Jiang: Nanjing University
Dan Yao: Nanjing University
Chuang Shen: Nanjing University of Posts and Telecommunications
Jiayue Su: Tsinghua University
Tao Liu: Tsinghua University
Jinhui Wu: Nanjing University
Zhimin Luo: Nanjing University of Posts and Telecommunications
Yiqiao Hu: Nanjing University
Ahu Yuan: Nanjing University
Nature Communications, 2024, vol. 15, issue 1, 1-18
Abstract:
Abstract Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by developing chiral vidarabine monophosphate-gadolinium nanowires (aAGd-NWs) through coordination-driven self-assembly. We elucidate the mechanism of aAGd-NW assembly and characterize their distinct features, which include a negative surface charge, ultrafine topography, and right-handed chirality. Additionally, aAGd-NWs not only enhance X-ray deposition but also inhibit DNA repair, thereby enhancing radiation-induced in situ vaccination. Consequently, the in situ vaccination induced by aAGd-NWs sensitizes radiation enhances CD8+ T-cell-dependent antitumor immunity and synergistically potentiates the efficacy immune checkpoint blockade therapies against both primary and metastatic tumors. The well-established aAGd-NWs exhibit exceptional therapeutic capacity and biocompatibility, offering a promising avenue for the development of radioimmunotherapy approaches.
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48423-w
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DOI: 10.1038/s41467-024-48423-w
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