A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

Qiming Shao, Ligu Chen, Xiaowan Li, Miao Li, Hui Cui, Xiaoyue Li, Xinran Zhao, Yuying Shi, Qiang Sun, Kaiyue Yan and Guangfu Wang ()
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Qiming Shao: Harbin Institute of Technology
Ligu Chen: Harbin Institute of Technology
Xiaowan Li: Harbin Institute of Technology
Miao Li: Harbin Institute of Technology
Hui Cui: Harbin Institute of Technology
Xiaoyue Li: Harbin Institute of Technology
Xinran Zhao: Harbin Institute of Technology
Yuying Shi: Harbin Institute of Technology
Qiang Sun: Harbin Institute of Technology
Kaiyue Yan: Harbin Institute of Technology
Guangfu Wang: Harbin Institute of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Visual information is important for accurate spatial coding and memory-guided navigation. As a crucial area for spatial cognition, the medial entorhinal cortex (MEC) harbors diverse spatially tuned cells and functions as the major gateway relaying sensory inputs to the hippocampus containing place cells. However, how visual information enters the MEC has not been fully understood. Here, we identify a pathway originating in the secondary visual cortex (V2) and directly targeting MEC layer 5a (L5a). L5a neurons served as a network hub for visual processing in the MEC by routing visual inputs from multiple V2 areas to other local neurons and hippocampal CA1. Interrupting this pathway severely impaired visual stimulus-evoked neural activity in the MEC and performance of mice in navigation tasks. These observations reveal a visual cortical-entorhinal pathway highlighting the role of MEC L5a in sensory information transmission, a function typically attributed to MEC superficial layers before.

Date: 2024
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DOI: 10.1038/s41467-024-48483-y

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