The mouse multi-organ proteome from infancy to adulthood

Qingwen Wang, Xinwen Ding, Zhixiao Xu, Boqian Wang, Aiting Wang, Liping Wang, Yi Ding, Sunfengda Song, Youming Chen, Shuang Zhang, Lai Jiang and Xianting Ding ()
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Qingwen Wang: Shanghai Jiao Tong University
Xinwen Ding: Shanghai Jiao Tong University
Zhixiao Xu: Shanghai Jiao Tong University
Boqian Wang: Shanghai Jiao Tong University
Aiting Wang: Shanghai Jiao Tong University
Liping Wang: Shanghai Jiao Tong University
Yi Ding: Shanghai Jiao Tong University
Sunfengda Song: Shanghai Jiao Tong University
Youming Chen: Shanghai Jiao Tong University
Shuang Zhang: Shanghai Jiao Tong University
Lai Jiang: Shanghai Jiao Tong University
Xianting Ding: Shanghai Jiao Tong University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The early-life organ development and maturation shape the fundamental blueprint for later-life phenotype. However, a multi-organ proteome atlas from infancy to adulthood is currently not available. Herein, we present a comprehensive proteomic analysis of ten mouse organs (brain, heart, lung, liver, kidney, spleen, stomach, intestine, muscle and skin) at three crucial developmental stages (1-, 4- and 8-weeks after birth) acquired using data-independent acquisition mass spectrometry. We detect and quantify 11,533 protein groups across the ten organs and obtain 115 age-related differentially expressed protein groups that are co-expressed in all organs from infancy to adulthood. We find that spliceosome proteins prevalently play crucial regulatory roles in the early-life development of multiple organs, and detect organ-specific expression patterns and sexual dimorphism. This multi-organ proteome atlas provides a fundamental resource for understanding the molecular mechanisms underlying early-life organ development and maturation.

Date: 2024
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DOI: 10.1038/s41467-024-50183-6

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