Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model

Alexander W. Stockinger, Leonie Adelmann, Martin Fahrenberger, Christine Ruta, B. Duygu Özpolat, Nadja Milivojev, Guillaume Balavoine () and Florian Raible ()
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Alexander W. Stockinger: Vienna Biocenter Campus (VBC)
Leonie Adelmann: Vienna Biocenter Campus (VBC)
Martin Fahrenberger: Vienna Biocenter Campus (VBC)
Christine Ruta: Federal University of Rio de Janeiro
B. Duygu Özpolat: Institut Jacques Monod
Nadja Milivojev: Vienna Biocenter Campus (VBC)
Guillaume Balavoine: Institut Jacques Monod
Florian Raible: Vienna Biocenter Campus (VBC)

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Regeneration of missing body parts can be observed in diverse animal phyla, but it remains unclear to which extent these capacities rely on shared or divergent principles. Research into this question requires detailed knowledge about the involved molecular and cellular principles in suitable reference models. By combining single-cell RNA sequencing and mosaic transgenesis in the marine annelid Platynereis dumerilii, we map cellular profiles and lineage restrictions during posterior regeneration. Our data reveal cell-type specific injury responses, re-expression of positional identity factors, and the re-emergence of stem cell signatures in multiple cell populations. Epidermis and mesodermal coelomic tissue produce distinct putative posterior stem cells (PSCs) in the emerging blastema. A novel mosaic transgenesis strategy reveals both developmental compartments and lineage restrictions during regenerative growth. Our work supports the notion that posterior regeneration involves dedifferentiation, and reveals molecular and mechanistic parallels between annelid and vertebrate regeneration.

Date: 2024
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DOI: 10.1038/s41467-024-54041-3

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