Microstructural asymmetry in the human cortex

Bin Wan (), Amin Saberi, Casey Paquola, H. Lina Schaare, Meike D. Hettwer, Jessica Royer, Alexandra John, Lena Dorfschmidt, Şeyma Bayrak, Richard A. I. Bethlehem, Simon B. Eickhoff, Boris C. Bernhardt and Sofie L. Valk ()
Additional contact information
Bin Wan: Max Planck Institute for Human Cognitive and Brain Sciences
Amin Saberi: Max Planck Institute for Human Cognitive and Brain Sciences
Casey Paquola: Research Center Jülich
H. Lina Schaare: Max Planck Institute for Human Cognitive and Brain Sciences
Meike D. Hettwer: Max Planck Institute for Human Cognitive and Brain Sciences
Jessica Royer: Montréal Neurological Institute and Hospital, McGill University
Alexandra John: Max Planck Institute for Human Cognitive and Brain Sciences
Lena Dorfschmidt: The Children’s Hospital of Philadelphia
Şeyma Bayrak: Max Planck Institute for Human Cognitive and Brain Sciences
Richard A. I. Bethlehem: University of Cambridge
Simon B. Eickhoff: Research Center Jülich
Boris C. Bernhardt: Montréal Neurological Institute and Hospital, McGill University
Sofie L. Valk: Max Planck Institute for Human Cognitive and Brain Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance.

Date: 2024
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DOI: 10.1038/s41467-024-54243-9

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