Ultra-fast photoelectron transfer in bimetallic porphyrin optoelectrode for single neuron modulation

Jian Chen, Feixiang Chen, Xueli Wang, Hongjun Zhuang, Mengnan Guo, Luo Wang, Junze Xie, Le Zhang, Hao Liu, Yuhan Shi, Jiajia Zhou, Xinjie Mao, Muyao Lv, Xingwu Jiang, Jinquan Chen (), Yanyan Liu (), Dayong Jin () and Wenbo Bu ()
Additional contact information
Jian Chen: Fudan University
Feixiang Chen: Fudan University
Xueli Wang: East China Normal University
Hongjun Zhuang: Xiamen University
Mengnan Guo: Fudan University
Luo Wang: Fudan University
Junze Xie: Fudan University
Le Zhang: University of Technology Sydney
Hao Liu: Fudan University
Yuhan Shi: Baylor College of medicine
Jiajia Zhou: University of Technology Sydney
Xinjie Mao: Fudan University
Muyao Lv: Fudan University
Xingwu Jiang: Fudan University
Jinquan Chen: East China Normal University
Yanyan Liu: Fudan University
Dayong Jin: University of Technology Sydney
Wenbo Bu: Fudan University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Shrinking the size of photoelectrodes into the nanoscale will enable the precise modulation of cellular and subcellular behaviors of a single neuron and neural circuits. However, compared to photovoltaic devices, the reduced size causes the compromised efficiencies. Here, we present a highly efficient nanoelectrode based on bimetallic zinc and gold porphyrin (ZnAuPN). Upon light excitation, we observe ultrafast energy transfer (~66 ps) and charge transfer (~0.5 ps) through the porphyrin ring, enabling 97% efficiency in separating and transferring photoinduced charges to single Au-atom centers. Leveraging these isolated Au atoms as stimulating electrode arrays, we achieve significant photocurrent injection in single neurons, triggering action potential with millisecond light pulses. Notably, Extracranial near-infrared light irradiation of the motor cortex induces neuronal firing and enhances mouse movement. These results show the potential of nanoscale optoelectrodes for high spatiotemporal modulation of neuronal networks without the need for gene transfection in optogenetics.

Date: 2024
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DOI: 10.1038/s41467-024-54325-8

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