Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus

Luca Zinzula (), Florian Beck, Marianna Camasta, Stefan Bohn, Chuan Liu, Dustin Morado, Andreas Bracher, Juergen M. Plitzko and Wolfgang Baumeister ()
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Luca Zinzula: Research Group Molecular Structural Biology
Florian Beck: Research Group Molecular Structural Biology
Marianna Camasta: Research Group Molecular Structural Biology
Stefan Bohn: Research Group Molecular Structural Biology
Chuan Liu: Research Group Molecular Structural Biology
Dustin Morado: Department of Cell and Virus Structure
Andreas Bracher: Department of Cellular Biochemistry
Juergen M. Plitzko: Research Group Molecular Structural Biology
Wolfgang Baumeister: Research Group Molecular Structural Biology

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.

Date: 2024
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DOI: 10.1038/s41467-024-54431-7

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