Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis

Chuan Peng, Yuling Zhu, Kaibo Zhang, Yiwei Wang, Yi Zheng, Yang Liu, Weili Fu (), Hong Tan, Qiang Fu and Mingming Ding ()
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Chuan Peng: Sichuan University
Yuling Zhu: Sichuan University
Kaibo Zhang: Sichuan University
Yiwei Wang: Sichuan University
Yi Zheng: Sichuan University
Yang Liu: Sichuan University
Weili Fu: Sichuan University
Hong Tan: Sichuan University
Qiang Fu: Sichuan University
Mingming Ding: Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen and oxygen atoms, which suffer from short emission wavelengths, low efficiency, limited responsiveness, and obscure luminescence mechanisms. Here we present an emission mechanism in bioactive polycysteine, an aliphatic polymer that displays polymerization- and aggregation-induced emission, high quantum yield, and multicolor emission properties. We show that the hydrogen atoms bonded to the sulfur atoms play a crucial role in luminescence. This enables reversible modulation of polymer fluorescence under reducing and oxidizing conditions, facilitating specific imaging and quantitative detection of redox species in cells and in vivo. Furthermore, the polymer exhibits better anti-inflammatory and antioxidative activities compared to first-line clinical antioxidants, offering a promising platform for in vivo theragnosis of diseases such as osteoarthritis.

Date: 2024
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DOI: 10.1038/s41467-024-54473-x

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