Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

Teofila Seremet, Jeremy Di Domizio, Antoine Girardin, Ahmad Yatim, Raphael Jenelten, Francesco Messina, Fanny Saidoune, Christoph Schlapbach, Sofia Bogiatzi, Frederic Minisini, Natalie Garzorz-Stark, Matthieu Leuenberger, Héloise Wüthrich, Maxime Vernez, Daniel Hohl, Stefanie Eyerich, Kilian Eyerich, Emmanuella Guenova, Carle Paul, Raphael Gottardo, Curdin Conrad and Michel Gilliet ()
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Teofila Seremet: Lausanne University Hospital CHUV and University of Lausanne
Jeremy Di Domizio: Lausanne University Hospital CHUV and University of Lausanne
Antoine Girardin: Lausanne University Hospital CHUV and University of Lausanne
Ahmad Yatim: Lausanne University Hospital CHUV and University of Lausanne
Raphael Jenelten: Lausanne University Hospital CHUV and University of Lausanne
Francesco Messina: Lausanne University Hospital CHUV and University of Lausanne
Fanny Saidoune: Lausanne University Hospital CHUV and University of Lausanne
Christoph Schlapbach: University of Bern
Sofia Bogiatzi: Lausanne University Hospital CHUV and University of Lausanne
Frederic Minisini: Lausanne University Hospital CHUV and University of Lausanne
Natalie Garzorz-Stark: University of Freiburg
Matthieu Leuenberger: Lausanne University Hospital CHUV and University of Lausanne
Héloise Wüthrich: Lausanne University Hospital CHUV and University of Lausanne
Maxime Vernez: Lausanne University Hospital CHUV and University of Lausanne
Daniel Hohl: Lausanne University Hospital CHUV and University of Lausanne
Stefanie Eyerich: University of Freiburg
Kilian Eyerich: University of Freiburg
Emmanuella Guenova: Lausanne University Hospital CHUV and University of Lausanne
Carle Paul: CHU Toulouse
Raphael Gottardo: and SIB
Curdin Conrad: Lausanne University Hospital CHUV and University of Lausanne
Michel Gilliet: Lausanne University Hospital CHUV and University of Lausanne

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.

Date: 2024
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DOI: 10.1038/s41467-024-54559-6

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