Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety

Zhiyi Chen (), Yancheng Tang, Xuerong Liu, Wei Li, Yuanyuan Hu, Bowen Hu, Ting Xu, Rong Zhang, Lei Xia, Jing-Xuan Zhang, Zhibing Xiao, Ji Chen, Zhengzhi Feng, Yuan Zhou (), Qinghua He, Jiang Qiu, Xu Lei, Hong Chen, Shaozheng Qin () and Tingyong Feng ()
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Zhiyi Chen: Third Military Medical University
Yancheng Tang: Shanghai International Studies University
Xuerong Liu: Third Military Medical University
Wei Li: Third Military Medical University
Yuanyuan Hu: Chinese Academy of Sciences
Bowen Hu: Beijing Normal University
Ting Xu: Southwest University
Rong Zhang: Southwest University
Lei Xia: Third Military Medical University
Jing-Xuan Zhang: Third Military Medical University
Zhibing Xiao: Beijing Normal University
Ji Chen: Shanghai Jiao Tong University
Zhengzhi Feng: Third Military Medical University
Yuan Zhou: Chinese Academy of Sciences
Qinghua He: Southwest University
Jiang Qiu: Southwest University
Xu Lei: Southwest University
Hong Chen: Southwest University
Shaozheng Qin: Beijing Normal University
Tingyong Feng: Southwest University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity.

Date: 2024
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DOI: 10.1038/s41467-024-55008-0

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