MamF-like proteins are distant Tic20 homologs involved in organelle assembly in bacteria

Anja Paulus, Frederik Ahrens, Annika Schraut, Hannah Hofmann, Tim Schiller, Thomas Sura, Dörte Becher and René Uebe ()
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Anja Paulus: University of Bayreuth
Frederik Ahrens: University of Bayreuth
Annika Schraut: University of Bayreuth
Hannah Hofmann: University of Bayreuth
Tim Schiller: University of Bayreuth
Thomas Sura: University of Greifswald
Dörte Becher: University of Greifswald
René Uebe: University of Bayreuth

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Organelle-specific protein translocation systems are essential for organelle biogenesis and maintenance in eukaryotes but thought to be absent from prokaryotic organelles. Here, we demonstrate that MamF-like proteins are crucial for the formation and functionality of bacterial magnetosome organelles. Deletion of mamF-like genes in the Alphaproteobacterium Magnetospirillum gryphiswaldense results in severe defects in organelle positioning, biomineralization, and magnetic navigation. These phenotypic defects result from the disrupted targeting of a subset of magnetosomal proteins that contain C-terminal glycine-rich integral membrane domains. Phylogenetic analyses reveal an ancient evolutionary link between MamF-like proteins and plastidial Tic20. Our findings redefine the molecular roles of MamF-like proteins and suggest that organelle-specific protein targeting systems also play a role in bacterial organelle formation.

Date: 2024
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DOI: 10.1038/s41467-024-55121-0

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