CEP signaling coordinates plant immunity with nitrogen status

Jakub Rzemieniewski, Henriette Leicher, Hyun Kyung Lee, Caroline Broyart, Shahran Nayem, Christian Wiese, Julian Maroschek, Zeynep Camgöz, Vilde Olsson Lalun, Michael Anthony Djordjevic, A. Corina Vlot, Ralph Hückelhoven, Julia Santiago and Martin Stegmann ()
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Jakub Rzemieniewski: Technical University of Munich
Henriette Leicher: Technical University of Munich
Hyun Kyung Lee: University of Lausanne
Caroline Broyart: University of Lausanne
Shahran Nayem: Institute of Biochemical Plant Pathology
Christian Wiese: Technical University of Munich
Julian Maroschek: Technical University of Munich
Zeynep Camgöz: Technical University of Munich
Vilde Olsson Lalun: University of Oslo
Michael Anthony Djordjevic: Australian National University
A. Corina Vlot: Institute of Biochemical Plant Pathology
Ralph Hückelhoven: Technical University of Munich
Julia Santiago: University of Lausanne
Martin Stegmann: Technical University of Munich

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Plant endogenous signaling peptides shape growth, development and adaptations to biotic and abiotic stress. Here, we identify C-TERMINALLY ENCODED PEPTIDEs (CEPs) as immune-modulatory phytocytokines in Arabidopsis thaliana. Our data reveals that CEPs induce immune outputs and are required to mount resistance against the leaf-infecting bacterial pathogen Pseudomonas syringae pv. tomato. We show that effective immunity requires CEP perception by tissue-specific CEP RECEPTOR 1 (CEPR1) and CEPR2. Moreover, we identify the related RECEPTOR-LIKE KINASE 7 (RLK7) as a CEP4-specific CEP receptor contributing to CEP-mediated immunity, suggesting a complex interplay of multiple CEP ligands and receptors in different tissues during biotic stress. CEPs have a known role in the regulation of root growth and systemic nitrogen (N)-demand signaling. We provide evidence that CEPs and their receptors promote immunity in an N status-dependent manner, suggesting a previously unknown molecular crosstalk between plant nutrition and cell surface immunity. We propose that CEPs and their receptors are central regulators for the adaptation of biotic stress responses to plant-available resources.

Date: 2024
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DOI: 10.1038/s41467-024-55194-x

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