Genetic footprints of assortative mating in the Japanese population

Kenichi Yamamoto, Kyuto Sonehara, Shinichi Namba, Takahiro Konuma, Hironori Masuko, Satoru Miyawaki, Yoichiro Kamatani, Nobuyuki Hizawa, Keiichi Ozono, Loic Yengo and Yukinori Okada ()
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Kenichi Yamamoto: Osaka University Graduate School of Medicine
Kyuto Sonehara: Osaka University Graduate School of Medicine
Shinichi Namba: Osaka University Graduate School of Medicine
Takahiro Konuma: Osaka University Graduate School of Medicine
Hironori Masuko: University of Tsukuba
Satoru Miyawaki: The University of Tokyo
Yoichiro Kamatani: The University of Tokyo
Nobuyuki Hizawa: University of Tsukuba
Keiichi Ozono: Osaka University Graduate School of Medicine
Loic Yengo: The University of Queensland
Yukinori Okada: Osaka University Graduate School of Medicine

Nature Human Behaviour, 2023, vol. 7, issue 1, 65-73

Abstract: Abstract Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.

Date: 2023
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DOI: 10.1038/s41562-022-01438-z

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