Topological domains in mammalian genomes identified by analysis of chromatin interactions

Jesse R. Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun S. Liu and Bing Ren (biren@ucsd.edu)
Additional contact information
Jesse R. Dixon: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Siddarth Selvaraj: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Feng Yue: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Audrey Kim: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Yan Li: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Yin Shen: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Ming Hu: Harvard University, 1 Oxford Street, Cambridge, Massachusetts 02138, USA
Jun S. Liu: Harvard University, 1 Oxford Street, Cambridge, Massachusetts 02138, USA
Bing Ren: Ludwig Institute for Cancer Research, 9500 Gilman Drive

Nature, 2012, vol. 485, issue 7398, 376-380

Abstract: The three-dimensional organization of the human and mouse genomes in embryonic stem cells and terminally differentiated cell types is investigated, revealing that large, megabase-sized chromatin interaction domains are a pervasive and conserved structural feature of genome organization.

Date: 2012
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DOI: 10.1038/nature11082

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