Inferring health conditions from fMRI-graph data

PierGianLuca Porta Mana, Claudia Bachmann and Abigail Morrison
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PierGianLuca Porta Mana: Norwegian University of Science and Technology

No r2huz, OSF Preprints from Center for Open Science

Abstract: Automated classification methods for disease diagnosis are currently in the limelight, especially for imaging data. Classification does not fully meet a clinician's needs, however: in order to combine the results of multiple tests and decide on a course of treatment, a clinician needs the likelihood of a given health condition rather than binary classification yielded by such methods. We illustrate how likelihoods can be derived step by step from first principles and approximations, and how they can be assessed and selected, using fMRI data from a publicly available data set containing schizophrenic and healthy control subjects, as a working example. We start from the basic assumption of partial exchangeability, and then the notion of sufficient statistics and the "method of translation" (Edgeworth, 1898) combined with conjugate priors. This method can be used to construct a likelihood that can be used to compare different data-reduction algorithms. Despite the simplifications and possibly unrealistic assumptions used to illustrate the method, we obtain classification results comparable to previous, more realistic studies about schizophrenia, whilst yielding likelihoods that can naturally be combined with the results of other diagnostic tests.

Date: 2018-01-30
New Economics Papers: this item is included in nep-hea
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Persistent link: https://EconPapers.repec.org/RePEc:osf:osfxxx:r2huz

DOI: 10.31219/osf.io/r2huz

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