Motifs in Brain Networks

Olaf Sporns and Rolf Kötter

PLOS Biology, 2004, vol. 2, issue 11, 1-

Abstract: Complex brains have evolved a highly efficient network architecture whose structural connectivity is capable of generating a large repertoire of functional states. We detect characteristic network building blocks (structural and functional motifs) in neuroanatomical data sets and identify a small set of structural motifs that occur in significantly increased numbers. Our analysis suggests the hypothesis that brain networks maximize both the number and the diversity of functional motifs, while the repertoire of structural motifs remains small. Using functional motif number as a cost function in an optimization algorithm, we obtain network topologies that resemble real brain networks across a broad spectrum of structural measures, including small-world attributes. These results are consistent with the hypothesis that highly evolved neural architectures are organized to maximize functional repertoires and to support highly efficient integration of information. Analysis of characteristic patterns of connectivity in neuroanatomical datasets suggests that nervous systems evolved to maximize functional repertoires and support highly efficient integration of information.

Date: 2004
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (15)

Downloads: (external link)
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0020369 (text/html)
https://journals.plos.org/plosbiology/article/file ... 20369&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pbio00:0020369

DOI: 10.1371/journal.pbio.0020369

Access Statistics for this article

More articles in PLOS Biology from Public Library of Science
Bibliographic data for series maintained by plosbiology ().