Value and Price of Multi-indication Cancer Drugs in the USA, Germany, France, England, Canada, Australia, and Scotland

Daniel Tobias Michaeli (), Mackenzie Mills and Panos Kanavos ()
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Daniel Tobias Michaeli: University Hospital Mannheim, Heidelberg University
Mackenzie Mills: London School of Economics and Political Science
Panos Kanavos: London School of Economics and Political Science

Applied Health Economics and Health Policy, 2022, vol. 20, issue 5, No 12, 757-768

Abstract: Abstract Purpose Oncology drugs are often approved for multiple indications, for which their clinical benefit varies. Aligning a single price to this differing value remains a challenge. This study examines the clinical and economic value, price, and reimbursement of multi-indication cancer drugs across seven countries, representing different approaches to value assessment, pricing, and coverage decisions: the USA, Germany, France, England, Canada, Australia, and Scotland. Methods Twenty-five multi-indication cancer drugs across 100 indications were identified with US Food and Drug Administration (FDA) approval between 2009 and 2019. For each indication data on Health Technology Assessment (HTA) recommendations, disease prevalence, and drug prices were obtained. Quality-adjusted life years (QALYs) gained, disease prevalence, list prices, and HTA outcomes were then compared across indications and regions. Results First approved indications provide a higher clinical benefit whilst targeting a smaller patient group than indication extensions. Quality-adjusted life year gains were higher for first (0.99, 95% CI 0.05–3.25) compared to second (0.51, 95% CI 0.02–1.63, p

Date: 2022
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DOI: 10.1007/s40258-022-00737-w

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