Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation

Lee S. Nguyen (), Mathieu Vautier, Yves Allenbach, Noel Zahr, Olivier Benveniste, Christian Funck-Brentano and Joe-Elie Salem
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Lee S. Nguyen: Sorbonne Université, AP-HP, INSERM
Mathieu Vautier: Sorbonne Université
Yves Allenbach: Sorbonne Université
Noel Zahr: Sorbonne Université, AP-HP, INSERM
Olivier Benveniste: Sorbonne Université
Christian Funck-Brentano: Sorbonne Université, AP-HP, INSERM
Joe-Elie Salem: Sorbonne Université, AP-HP, INSERM

Drug Safety, 2019, vol. 42, issue 7, No 2, 813-825

Abstract: Abstract Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative immunosuppressive drugs and have many clinical applications in various drug combinations. Experience in transplantation studies has been gained regarding the side effect profile of these drugs and the potential benefits and limitations compared with other immunosuppressive agents. This article reviews the adverse effects of mTOR inhibitors in solid organ transplantation, with special attention given to mechanisms hypothesized to cause adverse events and their management strategies.

Date: 2019
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DOI: 10.1007/s40264-019-00810-9

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