Cost-effectiveness of precision medicine: a scoping review

Miriam Kasztura (), Aude Richard, Nefti-Eboni Bempong, Dejan Loncar and Antoine Flahault
Additional contact information
Miriam Kasztura: Bern University of Applied Sciences
Aude Richard: University of Geneva
Nefti-Eboni Bempong: University of Geneva
Dejan Loncar: University of Geneva
Antoine Flahault: University of Geneva

International Journal of Public Health, 2019, vol. 64, issue 9, No 6, 1271 pages

Abstract: Abstract Objectives Precision medicine (PM) aims to improve patient outcomes by stratifying or individualizing diagnosis and treatment decisions. Previous reviews found inconclusive evidence as to the cost-effectiveness of PM. The purpose of this scoping review was to describe current research findings on the cost-effectiveness of PM and to identify characteristics of cost-effective interventions. Methods We searched PubMed with a combination of terms related to PM and economic evaluations and included studies published between 2014 and 2017. Results A total of 83 articles were included, of which two-thirds were published in Europe and the USA. The majority of studies concluded that the PM intervention was at least cost-effective compared to usual care. However, the willingness-to-pay thresholds varied widely. Key factors influencing cost-effectiveness included the prevalence of the genetic condition in the target population, costs of genetic testing and companion treatment and the probability of complications or mortality. Conclusions This review may help inform decisions about reimbursement, research and development of PM interventions.

Keywords: Precision medicine; Economic evaluation; Scoping review (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
http://link.springer.com/10.1007/s00038-019-01298-x Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:ijphth:v:64:y:2019:i:9:d:10.1007_s00038-019-01298-x

Ordering information: This journal article can be ordered from
http://www.springer.com/economics/journal/00038

DOI: 10.1007/s00038-019-01298-x

Access Statistics for this article

International Journal of Public Health is currently edited by Thomas Kohlmann, Nino Künzli and Andrea Madarasova Geckova

More articles in International Journal of Public Health from Springer, Swiss School of Public Health (SSPH+)
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().