A Systematic Review of Studies Comparing the Measurement Properties of the Three-Level and Five-Level Versions of the EQ-5D

Ines Buchholz (), Mathieu F. Janssen, Thomas Kohlmann and You-Shan Feng
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Ines Buchholz: Institute for Community Medicine, University Medicine of Greifswald
Mathieu F. Janssen: Erasmus MC
Thomas Kohlmann: Institute for Community Medicine, University Medicine of Greifswald
You-Shan Feng: Institute for Community Medicine, University Medicine of Greifswald

PharmacoEconomics, 2018, vol. 36, issue 6, No 3, 645-661

Abstract: Abstract Background Since the introduction of the five-level version of the EQ-5D (5L), many studies have comparatively investigated the measurement properties of the original three-level version (3L) with the 5L version. Objective The aim of this study was to consolidate the available evidence on the performance of both instruments. Methods A systematic literature search of studies in the English and German languages was conducted (2007–January 2018) using the PubMed, EMBASE, and PsycINFO (EBSCO) databases, as well as the EuroQol Research Foundation website. Data were extracted and assessed on missing values, distributional properties, informativity indices (Shannon’s H′ and J′), inconsistencies, responsiveness, and test–retest reliability. Results Twenty-four studies were included in the review. Missing values and floor effects (percentage reporting the worst health state) were found to be negligible for both 3L and 5L (

Date: 2018
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DOI: 10.1007/s40273-018-0642-5

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