Bayesian graphical models for modern biological applications

Yang Ni (), Veerabhadran Baladandayuthapani (), Marina Vannucci () and Francesco C. Stingo ()
Additional contact information
Yang Ni: Texas A&M University
Veerabhadran Baladandayuthapani: University of Michigan
Marina Vannucci: Rice University
Francesco C. Stingo: The University of Florence

Statistical Methods & Applications, 2022, vol. 31, issue 2, No 1, 197-225

Abstract: Abstract Graphical models are powerful tools that are regularly used to investigate complex dependence structures in high-throughput biomedical datasets. They allow for holistic, systems-level view of the various biological processes, for intuitive and rigorous understanding and interpretations. In the context of large networks, Bayesian approaches are particularly suitable because it encourages sparsity of the graphs, incorporate prior information, and most importantly account for uncertainty in the graph structure. These features are particularly important in applications with limited sample size, including genomics and imaging studies. In this paper, we review several recently developed techniques for the analysis of large networks under non-standard settings, including but not limited to, multiple graphs for data observed from multiple related subgroups, graphical regression approaches used for the analysis of networks that change with covariates, and other complex sampling and structural settings. We also illustrate the practical utility of some of these methods using examples in cancer genomics and neuroimaging.

Keywords: Graphical models; Bayesian methods; Complex data; Genomics; Neuroimaging (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/s10260-021-00572-8

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