 Effect of the degree of polar mismatching on traffic jam formation in fast axonal transportA.V. Kuznetsov Computer Methods in Biomechanics and Biomedical Engineering, 2010, vol. 13, issue 6, 711-722 Abstract: This paper simulates an axon with a region of reversed microtubule (MT) polarity, and investigates how the degree of polar mismatching in this region affects the formation of organelle traps in the axon. The model is based on modified Smith–Simmons equations governing molecular-motor-assisted transport in neurons. It is established that the structure that develops as a result of a region with disoriented MTs consists of two organelle traps, the trap to the left of this region accumulates plus-end-oriented organelles and the trap to the right of this region accumulates minus-end-oriented organelles. The presence of such a structure is shown to inhibit the transport of organelles down the axon. The degree by which the transport of organelles is inhibited depends on the degree of polar mismatching of MTs in the region between MT traps. Four cases with a different degree of polar mismatching are investigated. Date: 2010 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:13:y:2010:i:6:p:711-722 Ordering information: This journal article can be ordered from DOI: 10.1080/10255840903505154 Access Statistics for this article Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals |
Is your work missing from RePEc? Here is how to contribute.
Questions or problems? Check the EconPapers FAQ or send mail to .
EconPapers is hosted by the
School of Business at Örebro University.