Modeling developmental data using U-shaped threshold dose-response curves

Daniel Hunt and Dale Bowman

Journal of Applied Statistics, 2006, vol. 33, issue 1, 35-47

Abstract: This paper develops threshold models for developmental toxicity data. The distinguishing feature of these threshold models is their flexibility in modeling data below threshold with a U-shaped function if the data warrants. The method is applied to actual data from a developmental study which exhibits U-shaped behavior in early dose groups. Results from a simulation study demonstrate the flexibility of the threshold model to pick up on U-shaped trends in the data. In addition, the simulation study reveals important considerations in design of developmental studies.

Keywords: Beta-binomial; dose-response curves; threshold models; U-shaped models (search for similar items in EconPapers)
Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:taf:japsta:v:33:y:2006:i:1:p:35-47

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DOI: 10.1080/02664760500389525

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