A finite sample comparison of nonparametric estimates of the effective dose in quantal bioassay

Holger Dette and Regine Scheder

No 2008,05, Technical Reports from Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen

Abstract: To estimate the effective dose level ED a in the common binary response model, several parametric and nonparametric estimators have been proposed in the literature. In the present paper, we focus on nonparametric methods and present a detailed numerical comparison of four different approaches to estimate the ED a nonparametrically. The methods are briefly reviewed and their finite sample properties are studied by means of a detailed simulation study. Moreover, a data example is presented to illustrate the different concepts.

Keywords: Binary response model; effective dose level; nonparametric regression; isotonic regression; order restricted inference; local linear regression (search for similar items in EconPapers)
Date: 2008
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Persistent link: https://EconPapers.repec.org/RePEc:zbw:sfb475:200805

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