Molecular detection of GSTM and GSTT genes with biomarkers studies in samples of Iraqi breast cancer patients

Hasan Alhayali () and Zohreh Hojati ()

International Journal of Innovative Research and Scientific Studies, 2025, vol. 8, issue 3, 2884-2895

Abstract: To identify genes like GSTT and GSTM's impact on breast cancer development, as well as their relationship with age, blood group, white blood cell count, erythrocyte sedimentation rate, and lipoprotein levels. Genomic DNA was extracted from blood samples of 75 breast cancer cases and 40 control subjects, and detection was performed using multiplex PCR-based methods and biomarker examination. Gel electrophoresis showed significant differences in nucleic acid bands from GSTT and GSTM genes in patients with breast cancer. The Type O blood group was more prevalent, with a significantly higher age (51.74 ±1.56) compared to the control groups (34.50 ±3.03). White blood cell count was also significantly higher in the breast cancer group. The study revealed significant differences in erythrocyte sedimentation rate, high-density lipoprotein, and low-density lipoprotein levels in breast cancer patients compared to control groups, with both groups showing higher levels of these markers. The study indicates that GSTT and GSTM may increase breast cancer susceptibility, with the Type O blood group being more prevalent in patients. Other factors, such as white blood cell count, erythrocyte sedimentation rate, high-density lipoprotein, low-density lipoprotein, immunoglobulin G, and blood sugar, were also significantly higher in patients with breast cancer.

Keywords: Breast cancer risk; GSTM; GSTT; Iraq. (search for similar items in EconPapers)
Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijirss.com/index.php/ijirss/article/view/7096/1476 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:aac:ijirss:v:8:y:2025:i:3:p:2884-2895:id:7096

Access Statistics for this article

International Journal of Innovative Research and Scientific Studies is currently edited by Natalie Jean

More articles in International Journal of Innovative Research and Scientific Studies from Innovative Research Publishing
Bibliographic data for series maintained by Natalie Jean ().